Lefu la pelo la migraine , le tsejoang ke lihlooho tse bohloko le tse utloisang bohloko, li tloaelehile mehleng ena. Ha ho phekoloa migraine, ho sebelisoa lihlopha tse fapa-fapaneng, 'me meriana ka boeona e reretsoe ho hlasela migraine ka bobeli le ho e thibela (thibelo). Khetho ea lithethefatsi tsa antimigrenous e etsoa bakeng sa bakuli ka bomong, ho na le lintlha tse bakang maikutlo, litšobotsi tsa maikutlo, boteng ba mafu a khotsofatsang, bothata ba bohloko, joalo-joalo.
E 'ngoe ea meriana e sebetsang ka ho fetisisa bakeng sa ho felisa matšoao a migraine ke litokisetso tsa sehlopha sa triptans. Li-triptane li laeloa lithethefatsi tse sa thuseng feela ho fokotsa matšoao a bohloko le a eketsehileng a matšoao a migraine, empa le ho fokotsa lebelo la ho oela.
Mokhoa oa liketso tsa triptan
Li-triptans ke meriana ea migraine, e khothalletsoang ho bakuli ba nang le mathata a tebileng (litlhaselo), hammoho le boemo bo bongata ba ho se sebetse. Li-triptans li tsoa ho serotonin, mokena-lipakeng oa tsamaiso ea methapo.
Mokhoa o nepahetseng le o feletseng oa liketso tsa lithethefatsi tsa sehlopha sena ha o e-s'o ithute ka ho lekaneng ho fihlela joale. Ho nahanoa hore meriana ena e loantša litlhaselo tsa migraine, e na le liphello tse kholo tse latelang ho "trigeminovascular system" (neurons ea methapo ea methapo ea litlhapi le mekhoa ea bokooa e sa lebelloang, e leng khokahanyo ea bohlokoa ho "ts'oaetso" ea tlhaselo):
- ho thibela mokhoa oa trigeminal nerve system (neuroinhibitory effect);
- mekhoa e mengata ea cerebrospinal le lijana tsa likarolo tsa boko le ho fokotsa tšollo ea mali ho tsona (khato ea vasoconstrictor).
Re lokela ho hlokomela hore triptans ha e ama methapo e meng ea mali ea 'mele oa motho.
Mefuta ea triptans
Triptan ea pele, e qalileng ho sebelisoa bakeng sa migraine, ke sumatriptan. Tšebeliso ea sesebelisoa sena, thuto ea sona, liteko tsa kliniki li lumeletse ho ntlafatsa liphello tsa triptans le ho hlahisa lithethefatsi tse ncha, tse atlehang haholoanyane. Ho fihlela joale, meriana e tummeng ka ho fetisisa le e sebelisoang haholo ho tsoa sehlopheng sa triptan ke:
- Naratriptan;
- Frovatriptan;
- Eletriptan;
- Risotriptan;
- Zolmitriptan;
- Almotriptan le ba bang.
Ka molao, li-triptan li fumaneha ka mokhoa oa matlapa bakeng sa tsamaiso ea molomo. Leha ho le joalo, ho boetse ho etsoa litokisetso tsa sehlopha sena bakeng sa intranasal (sprays) le li-injection tse ka tlaase (li-injections), hammoho le triptans ka mokhoa oa li-suppositories tsa mahlakore.
Likarolo tsa triptans
Tryptans e lokela ho nkoa kapele ka mor'a ho qala ha matšoao a pele a tlhaselo ea migraine. Matlapa a ke ke a longoa, a lokela ho hlatsoa ka metsi a mangata. Ka molao, letlapa le leng le lekane ho emisa tlhaselo. Haeba bohloko bo sa fokotsehe, pilisi e latelang e ka nkoa ka mor'a lihora tse 2. Matlafatsa phello ea tšebeliso e kopanetsoeng ea lithethefatsi tsa sehlopha sena le lithethefatsi tse seng tsa steroidal tse khahlanong le ho ruruha (ka khothatso ea ngaka).
U se ke ua nka triptan nakong ea migraine aura . Ka ts'oaetso e matla le ho hlatsa, litsela tsa mahlakoreng, li-intranasal kapa tse ling tsa tsamaiso li khethoa. Tryptans e ke ke ea nkoa hangata ho feta makhetlo a 2 ka beke. U ke ke oa kopanya tšebeliso ea bona le lithibela-mafu, likokoana-hloko kapa li-anti-depressants.
Li kotsi hakae ke li-triptans?
Liphuputso tsa meriana ea meriana li bontša ho mamellana hantle ha li-triptans ho bakuli ba fapaneng.
Triptans li hanyetsanoa maemong a joalo:
- lefu la khatello ea mali;
- maloetse a sa foleng a ho tsamaisoa ha masapo;
- ho hloleha ha pelo;
- lefu la pelo la kelello;
- ho se sebetse ho matla haholo le ho senya;
- ho ima le lactation.