Lithethefatsi tsa li-anticoagulants li etselitsoe ho fokotsa tšollo ea mali ka ho thibela sebopeho sa fibrin. Tšusumetso ena e sitisa ho thehoa ha mali. Sesebelisoa sena se sebelisetsoa maloetse ka bobeli le e le moemeli oa thibelo. Litokisetso tsa Antikoagulant li ka ba matlapeng, joaloka liente kapa mafura. Khetho ea ho qetela e tloaelehile haholo. Tabeng ena, ke mofuta ofe le bongata bo hlokahalang ho nka motsoako ona, ke setsebi se lokelang ho etsa qeto, ho seng joalo meriana e ka baka sesosa feela, empa hape e bakela mathata a tebileng.
Li-anticoagulants li arotsoe ka litokisetso tsa ketso e tobileng le e sa tobang. Phapang e khōlō pakeng tsa lihlopha tsena tse peli ke hore na e thibela ho thehoa ha thrombi joang. Hape ke habohlokoa hore na litokisetso li amana joang le li-anticoagulants tsa mefuta e sa tšoaneng.
Li-anticoagulants tsa khato e tobileng
Litokisetso tsa li-anticoagulants tsa ketso e tobileng li khone ho thibela ketso ea ho thetsa. Sena se ka etsahala ha ho na le li-plasma cofactors. E ka sehloohong har'a bona ke antithrombin III.
Lithethefatsi tse joalo li tsoa sehlopheng sa batho ba sa tsebeng ka ho toba hore na li-inhibitor li bakoa ke eng, li boetse li bitsoa antithrombin III-e itšetlehileng ka thrombin inhibitors. Sehlopha sena se akarelletsa heparin e tlaase le e bohareng:
- heparin sodium;
- heparin calcium;
- supraparin calcium;
- enoxaparin sodium;
- parnaparin sodium
- sodium ea reviparin;
- cybernyne;
- deltaparin sodium;
- sodium ea hydrocitrate.
Heparin o khona ho emisa mosebetsi oa lintho tse ling tsa hemostasis. Pele ho tsohle, sena se bolela kallikrein, IXa, Xa, Xia, XIIa.
Lethathamo la litokisetso tsa li-anticoagulants tse tobileng:
- Lyoton 1000 (gel);
- Xarelto (matlapa);
- Dolabene (gel);
- Heparin (liente);
- Heparin Acrigel 1000 (gel);
- Venitane H (tranelate);
- Venolife;
- Ho tsuba (gel);
- Gepatrombin G (mafura).
Li-anticoagulants tsa ketso e sa tobang
Li-anticoagulants tsa phello e tobileng li kenyelletsa lithethefatsi tse senyang thrombin, e leng hantle, e atlehang ho feta ho emisa mosebetsi oa eona. Sehlopha sena sa anticoagulants se kenyelletsa hirudin le lipapiso tsa eona tse entsoeng, tse kenyeletsang:
- girugen;
- girulog;
- marang-rang;
- RASK.
Litokisetso tse sa tobang li-anticoagulants li bitsoa selective kapa li tobite tse tobileng tsa thrombin, kaha ha li itšetlehe ka antithrombin III ka thrombin inhibitors.
Lethathamo la litokisetso tsa li-anticoagulants tsa ketso e sa tobang:
- Warfarin Nycomed (matlapa);
- Phenylline (matlapa).
Litlhōlisano
Li-anticoagulants li na le li-contraction, tse ka bakang liphello tse tebileng. Ka hona, moriana o ke ke oa fuoa batho ba nang le maloetse le maloetse a latelang:
- maloetse a tšoaetso ea maling a nang le tšekamelo ea ho tsoa mali (mohlala, peptic seso, ho tsoa mali a tsoang mali);
- maloetse a sebete, ho kopanyelletsa le mak'hadinale fibrosis sebeteng, lefu la sebete le sa foleng;
- urolithiasis;
- lipontšo tsa ho hloleha ha liphio;
- maloetse a mali, moo mekhoa ea hemostatic e tlōloang (mohlala, thrombocytopenic purpura);
- Ho haella ha C-le K-vithamine;
- phehella septic endocrine;
- lefuba la matšoafo la mahlaba.
Hape ha ho kgothaletswe ho noa meriana le anticoagulants bakeng sa bakhachane.
Litla-morao
Lithethefatsi tsa anticoagulant li na le litla-morao tse 'maloa tse lokelang ho nkoa pele li noa meriana. Tsena li kenyelletsa:
- ho tsoa hohle ;
- hlooho, feberu, asthenia;
- necrosis ea letlalo;
- mosebetsi oa liphio o holofetseng;
- ho hlajoa ke pelo, ponahalo ea lisosa molomong, bohloko ba mpeng, bothata ba ho latsoa, letšollo, ho hlatsa le ho hlatsa;
- ho rata litsebi;
- ho hlohlona, ho phatloha, ho lefatla;
- ho senya liphio.