Likokoana-hloko tsa sebete - ena ke e 'ngoe ea likarolo tsa bohlokoa ka ho fetisisa tsa lik'hemik'hale tsa' mele 'meleng. Kaha sebete se etsa mesebetsi e mengata, li-enzyme tse entsoeng ka eona li arotsoe ka lihlopha tse ngata: excretory, indicator le secretory. Kaha ho na le maloetse a fapa-fapaneng le tšenyo ea sebete maling a mali, li-enzyme li fetoha. Ketsahalo ena ke pontšo ea bohlokoa ea ho hlahloba.
Ke li-enzyme tsa sebete tse sebelisetsoang ho hlahlojoa?
Li-enzyme tsa sebete, tseo tse ling tsa tsona li ka eketsehang maloetse a tsamaeang le timetso ea hepatocyte, e bitsoa li-enzyme tse bonts'ang. Tsena li kenyelletsa:
- glutamate dehydrogenase (Gldg);
- aspartate aminotransferase (AST);
- lactate dehydrogenase (LDH);
- gamma-glutamyltransferase (GGT);
- alanine aminotransferase (ALT).
Hangata, lefu la sebete le laeloa tlhahlobo ea mali bakeng sa boikemisetso ba enzyme ea AST le ALT. Bakeng sa basali, tloaelo ea ACT ke 20-40 U / l. Ka tšenyo e mpe ea likokoana-hloko tsa hepatocytes, li-enzyme tsena li phahamisa mosebetsi haholo.
Se tloaelehileng se nang le li-enzyme tsa sebete ALT maling ke 12-32 U / l (basali). Ka maloetse a tšoaetsanoang, mosebetsi oa bona o eketsa haholo - ka makhetlo a mangata. Tabeng ena, matšoao a meriana a lefu lena a ka 'na a ba sieo. Ke kahoo ALT e atisang ho sebelisoa ho lemoha lefu la sebete nakong ea pele.
Sesebelisoa se seng sa ho hlahloba ke Rite ea coefficient (AST / ALT lebelo). Ho motho ea phetseng hantle, ke 1.3.
Litlhahlobo tse ling tse hlakileng tsa lik'hemik'hale
E le hore ho be le phapang e nepahetseng haholoanyane ea maloetse, laboratori e ka boela ea hlahloba tlhahlobo le ho fumana li-enzyme tse phahameng tsa sebete maling. Maemong a sa tšoaneng a likokoanyana tse sebetsang sebeteng, mafu a seoa, tlhaselo e matla le maloetse a tšoaetsanoang, sekhobo sa Gldg ea mokuli (ka
Karolo e 'ngoe ea li-enzyme tsa sebete li kenngoa ka har'a li-ducts tsa bile. Ba kenya letsoho tšebetsong ea lijo. Enzyme e joalo ke alkaline phosphatase. Ka tloaelo lintho tse entsoeng ka lichelete tsa lefats'e tsa alkaline ha lia lokela ho feta 120 U / l. Empa haeba mekhoa ea metsoako ea metsoako e tlōloa, lenane lena le eketsa hoo e batlang e le 400 U / l.