Ts'ebetso e 'ngoe le e' ngoe ea 'mele ea mosebetsi oa bohlokoa oa' mele oa motho o fanoa ke lihomone tse fapa-fapaneng, tse hlahisoang ke litšoelesa tsa sephiring.
ACTH ke eng?
Hormone ea Adrenocorticotropic ke hormone ea peptide, e hlahisoang ke lesela la pituitary le ho laola mosebetsi oa adrenal cortex. Ka lehlakoreng le leng, litšoelesa tsa adrenal li hlahisa li-hormone tsa glucocorticoid le ho li sireletsa tsamaisong ea potoloho. Haeba hormone ea adrenocorticotropic e hlahisoa ka bongata, tšollo ea mali e eketsa mofuteng oa adrenal, 'me moloko o hōla. Ka lehlakoreng le leng, haeba ACTH e sa hlahisoe ka ho lekaneng, e ka atrophy. Hormone ea Corticotropic e boetse e tsejoa e le corticotropin, 'me meriking e sebelisa lebitso le khutsufatsang - ACTH.
Mesebetsi ea hormone ea adrenocorticotropic (ACTH)
Matšoao a li-hormone a tsejoang ke adrenal cortex corticotropin e laoloa ke molao-motheo oa maikutlo: palo ea corticotropin e hlahisoang ke lesela la pituitary e eketsa kapa e theoha ha ho hlokahala.
Hormone ea Adrenocorticotropic e ama tlhahiso ea lihomone tse latelang:
- li-glucocorticoids, haholo-holo cortisol le cortisone, tse tsejoang e le lihomone tse hanyetsang le tse hanyetsang khatello ea kelello;
- li-hormone tsa thobalano, tse ikarabellang bakeng sa bokhachane le mosebetsi oa ho ikatisa;
- karolo e 'ngoe bakeng sa tlhahiso ea adrenaline.
Ho latela tse ka holimo, re ka fihlela qeto ea hore hormone ea adrenocorticotropic e ikarabella ka ho toba bakeng sa:
- ho hanyetsa 'mele ho ea tšoaetsong;
- ho ikamahanya le maemo a macha;
- ho pholoha maemong a sithabetsang;
- bokhoni ba ho hlahisa bana.
Boemo ba ACTH maling a fetoha ho pholletsa le letsatsi. Boholo ba corticotropin bo hlokomeloa ka 7-8 hora hoseng, 'me mantsiboeeng tlhahiso ea eona e fokotseha, e theoha ho fokotsa letsatsi le leng le le leng. Ho ikitlaetsa ka ho feteletseng, khatello ea maikutlo le mathata a li-hormone ho basali ba ka boela ba ama palo ea hormone ea adrenocorticotropic maling. Maemo a ACTH a eketsehileng kapa a theohile a na le phello e mpe mosebetsing oa 'mele' me e ka 'na ea e-ba letšoao la maloetse a tebileng.
Haeba ACTH e phahame
Hormone ea Adrenocorticotropic e phahame maloetse a joalo:
- lefu la ectopic tlhahiso ea ACTH ha hormone ena e qala ho hlahisa hlahala e hlahileng ho e 'ngoe e' ngoe;
- Lefu la Addison kapa lefu la congenital la mokokotlo oa adrenal;
- Lefu la Itzenko-Cushing, le hlahang ka lebaka la pituitary adenoma;
- ka mor'a ho kenella ka ho buoa bakeng sa ho tlosoa ha li-gland tsa adrenal;
- paraneoplastic syndrome, eo ho eona ho nang le karabelo e ikhethang ea sekhahla sa pituitary ho sehlahala se bolaeang, hangata li-pancreas.
Hape, boemo ba ACTH bo eketseha le ho sebelisa lithethefatsi tse itseng, mohlala, insulin, amphetamine kapa litokisetso tsa lithium.
Haeba ACTH e theoha
Hormone ea Adrenocorticotropic e theoha ka ho latellana ho latelang:
- ho fokotsa mosebetsi oa pituitary ;
- ho fokotsa mosebetsi oa adrenal cortex;
- ha ho na le li-neoplasms tsa litšoelesa tsa adrenal;
- le phekolo ea hormone, ha bakuli ba nka glucocorticoids;
- maloetse a bronchial le a matšoafo.
Hape hoa lokela ho hlokomeloa hore ngaka e ka fana ka tlhahlobo ea likarolo tsa serame tsa ACTH haeba matšoao a latelang a hlokomeloa:
- mokhathala o eketsehileng;
- khatello ea khatello;
- boloetse bo sa foleng ba mokhathala;
- khatello ea kelello.
Hape, ho etsoa phuputso e tšoanang ho hlokomela boemo ba 'mele ha o phekola lithethefatsi tsa hormone.
U se ke ua hlokomoloha ho khethoa ha ngaka ho etsa tlhahlobo ea boemo ba ACTH. Ka liphello tsa eona, u ka beha nako e nepahetseng ea ho hlahlojoa ka nako 'me u qala phekolo e lekaneng.