Glucocorticoids ke mofuta oa li-hormone tse hlahisitsoeng ka lebaka la mosebetsi oa adrenal cortex. E 'ngoe ea lihomone ke cortisone, eo nakong ea sebete e sebetsang e fetoha e' ngoe hormone - hydrocortisone (cortisol). Cortisol ke hormone e tummeng ka ho fetisisa le ea bohlokoa bakeng sa 'mele oa motho. Meriana e thehiloeng ho li-hormone tsena e 'nile ea sebelisoa ho tloha lilemong tse 40 tsa lekholong la ho qetela la lilemo.
Mefuta ea lihomone tsa maiketsetso
Ho fihlela joale, ho phaella ho li-glucocorticoids tsa tlhaho, ho na le lithethefatsi tse 'maloa, tse ka sehloohong ho lihomone tsa maiketsetso, tse arotsoeng ka mefuta e' meli:
- fluorinated (dexamethasone, betamethasone, joalo-joalo);
- e seng fluorinated (prednisone, prednisolone).
Li khetholloa ka katleho e kholo ha li ja moriana o tlase. Ho feta moo, li-glucocorticoids li na le phello e tlaase ka ho fetisisa ea litla-morao.
Tšebeliso ea lithethefatsi-glucocorticoids
Litokisetso le li-glucocorticoids, li sebelisetsoa palo e kholo ea maloetse a tebileng, tk. ba na le liphello tse fapaneng 'meleng.
Mekhahlelo e mengata ea ho hlalosa lithethefatsi tsa sehlopha sena ke:
- lefu la ho fokola ha pelo ;
- ramatiki ea ramatiki;
- lefuemia;
- mononucleosis;
- mafu a letlalo (dermatitis, eczema);
- khaello ea mali;
- pneumonia;
- mafu a ho kula;
- ho fokola;
- hepatitis.
Mechine ea ho pepeseha ha e utloisisoe ka botlalo, empa phello ea tšebeliso ea glucocorticoids e ka ba khahlanong le ho ruruha, ho itšireletsa mafung, ho loantšana le bothata, ho khahlanong le tšabo. Litokisetso li ntšoa ka mefuta e sa tšoaneng:
- sprays;
- matlapa;
- lithōko;
- mafura;
- mokelikeli bakeng sa ente le ho inhalation.
Lethathamo la lithethefatsi-glucocorticoids
Lethathamo la mekhoa e joalo le leholo haholo. Tse tummeng ka ho fetisisa le tse atlehang ke tsena:
- Cortisone - e kenella phekolo ea phetolo;
- Prednisolone - ka makhetlo a mane a atlehang ho feta Hydrocortisone;
- Prednisone - ha e khothalletsoe bakeng sa mathata a sebete;
- Methylprednisolone - e loketseng ho phekola bakuli ba nang le botenya bo boholo, mathata a kelello, lisosa;
- Triamcinolone - e na le tšusumetso e ngata ho feta prednisolone, e nang le litla-morao tse boleloang ke mesifa le letlalo;
- Dexamethasone ke tokisetso e atlehang bakeng sa tšebeliso ea nako e khutšoanyane;
- Betamethasone ke moriana o haufi le dexamethasone.
Litla-morao tsa glucocorticoids
Ho fumana mefuta e mengata ea phekolo e nepahetseng, glucocorticoids ha e na litla-morao tse tsotehang. Ke ka lebaka leo hangata ba khethiloeng hore e be lithuto tse khutšoanyane kapa tse sebelisoang maemong a thata haholo. Litokisetso tsa sehlopha sa glucocorticoids li ka baka liketso tse latelang tse sa rateheng:
- ho fokola ha masapo, hlooho ea bofumahali ea necrosis;
- ho fokola ha masapo;
- fokotseha turgor ea letlalo;
- ponahalo ea streaks, thinning, haemorrhages;
- ho eketsa boima ba 'mele;
- ho tlōla boemo ba kelello;
- lefu la tsoekere;
- ho thibela bokhachane;
- mathata a tšoaetso ea mali (esophagitis, gastric le ho tsoa madi a enteng).
- mafu a mafura ( glaucoma , cataract).